Ad
related to: rh incompatibility signs and symptoms
Search results
Results From The WOW.Com Content Network
Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only the ...
An acute hemolytic transfusion reaction (AHTR), also called immediate hemolytic transfusion reaction, is a life-threatening reaction to receiving a blood transfusion.AHTRs occur within 24 hours of the transfusion and can be triggered by a few milliliters of blood.
Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis fetalis, [1] [2] is an alloimmune condition that develops in a fetus at or around birth, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta.
Symptoms may include a drop in hemoglobin level, fever, jaundice, or hemoglobinuria. [6] It is also "associated with a fall in Hb or failure to increment, rise in bilirubin and LDH and an incompatible crossmatch not detectable pre transfusion." [10] DHTR may be diagnosed by the presence of antibodies that react to red blood cells.
Cell-free DNA can be used the determine the Rh antigen of the fetus when the mother is Rh negative. Blood is taken from the mother during the pregnancy, and using PCR, can detect the K, C, c, D, and E alleles of fetal DNA. This blood test is non-invasive to the fetus and is an easy way of checking antigen status and risk of HDN.
These are typically signs of hydrops fetalis. [5] After birth, the symptoms of the child are similar to that of incompatible blood transfusion in adults. The baby may have pale skin due to anaemia. The yellowing of the umbilical cord, skin and eyes, also known as jaundice, may arise within 24 to 36 hours of birth. [5]
Hemolysis caused by the Rh incompatibility, causes extramedullary hematopoiesis in the fetal liver and bone marrow. [6] The push to make more erythroblasts to help compensate with the hemolysis over works the liver causing hepatomegaly. The resulting liver dysfunction decreases albumin output which in turn decreases oncotic pressure ...
Rh disease (Rh D) ABO hemolytic disease of the newborn; Anti-Kell hemolytic disease of the newborn; Rhesus c hemolytic disease of the newborn; Rhesus E hemolytic disease of the newborn; Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others) Drug induced immune mediated hemolytic anemia Penicillin (high dose) Methyldopa