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An immune system disorder but not an autoimmune disease. IPEX syndrome: A genetic mutation in FOXP3 that leads to autoimmune diseases, but not an autoimmune disorder itself. Ligneous conjunctivitis: No consistent evidence of association with autoimmunity. Majeed syndrome: No consistent evidence of association with autoimmunity. Narcolepsy
The exact causes of autoimmune diseases remain unclear and are likely multifactorial, involving both genetic and environmental influences. [7] While some diseases like lupus exhibit familial aggregation, suggesting a genetic predisposition , other cases have been associated with infectious triggers or exposure to environmental factors, implying ...
Research suggests a strong genetic susceptibility when it comes to autoimmune thyroid diseases like Hashimoto's thyroiditis as well as an epigenetic role in the pathology of Hashimoto's thyroiditis. The thyroglobulin (Tg) gene, a gene involved in the synthesis of the thyroid hormones, thyroxine and triiodothyronine, plays an important role in ...
Most autoimmune diseases are sex-related; as a whole, women are much more likely to develop autoimmune disease than men. Being female is the single greatest risk factor for developing autoimmune disease than any other genetic or environmental risk factor yet discovered.
Autoimmune diseases, such as type 1 diabetes, are complex genetic traits which result from defects in the immune system. Identification of genes defining the immune defects may identify new target genes for therapeutic approaches. Alternatively, genetic variations can also help to define the immunological pathway leading to disease.
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. [5] There are at least 80 types of autoimmune diseases. [5] Nearly any body part can be involved. Common symptoms include low-grade fever and feeling tired. [5] Often symptoms come and go. [5]
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