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The most common cause of primary adrenal insufficiency (Addison's disease) overall is autoimmune adrenalitis. [2] The prevalence of Addison's disease ranges from 5 to 221 per million in different countries. [30] In children, congenital adrenal hyperplasia (CAH) is the most common cause of adrenal insufficiency, with an incidence 1 in 14,200 ...
Addison's disease, also known as primary adrenal insufficiency, [4] is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands (adrenal cortex), causing adrenal insufficiency.
The authors felt neither pituitary nor adrenal insufficiency was involved, but that direct neural control of renal proximal tubular reabsorption of sodium was disrupted. [25] In 1953, Leaf et al, demonstrated that exogenous administration of the antidiuretic hormone vasopressin resulted in hyponatremia and a natriuresis dependent on water ...
Tumors on the pituitary gland or cancer metastasis can also cause adrenal insufficiency. [10] Exogenous steroid use is the most frequent cause of adrenal insufficiency, and those who use steroids also run the risk of experiencing an adrenal crisis. Adrenal crisis can be triggered by abrupt, and frequently unintentional, steroid withdrawal.
Electrolyte imbalance, or water-electrolyte imbalance, is an abnormality in the concentration of electrolytes in the body. Electrolytes play a vital role in maintaining homeostasis in the body. They help to regulate heart and neurological function, fluid balance , oxygen delivery , acid–base balance and much more.
Common side effects include numbness, ringing in the ears, loss of appetite, vomiting, and sleepiness. [2] It is not recommended in those with significant kidney problems, liver problems, or who are allergic to sulfonamides. [2] [4] Acetazolamide is in the diuretic and carbonic anhydrase inhibitor families of medication. [2]
Adrenal crisis is a serious, life-threatening complication of adrenal insufficiency. Hypotension , or hypovolemic shock , is the main symptom of adrenal crisis, other indications and symptoms include weakness , anorexia , nausea , vomiting, fever, fatigue , abnormal electrolytes , confusion , and coma. [ 19 ]
Glucocorticoid therapy in CAH impairs working memory and causes brain changes, including white matter hyperintensities, suggesting a reduction in white matter structural integrity. [12] Cognitive impairment, when observed, has occasionally been attributed to hypoglycemia and electrolyte imbalances at the initial presentation. [12]