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15–50% (with sudden stopping) [3] [4] Antidepressant discontinuation syndrome , also called antidepressant withdrawal syndrome , is a condition that can occur following the interruption, reduction, or discontinuation of antidepressant medication following its continuous use of at least a month. [ 5 ]
Amitriptyline is effective for the treatment of irritable bowel syndrome; however, because of its side effects, it should be reserved for select patients for whom other agents do not work. [ 41 ] [ 42 ] [ 43 ] There is insufficient evidence to support its use for abdominal pain in children with functional gastrointestinal disorders.
Deprescribing can improve adherence, cost, and health outcomes but may have adverse drug withdrawal effects. More specifically, deprescribing is the planned and supervised process of intentionally stopping a medication or reducing its dose to improve the person's health or reduce the risk of adverse side effects. Deprescribing is usually done ...
Some side effects, such as weight gain, occur more frequently with certain types of antidepressant medication. Switching to a new type of antidepressant may help reverse any weight gain you’ve ...
Intimate side effects like ED are known to occur with many antidepressants, including the following common medications: Citalopram (generic for Celexa) Sertraline (Zoloft)
Discontinuation of treatment due to side effects was common. [64] Antidepressants including amitriptyline, fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole are recommended by the European League Against Rheumatism (EULAR) for the treatment of fibromyalgia based on "limited evidence". [65]
The side effects of the TCAs usually come to prominence before the therapeutic benefits against depression and/or anxiety do, and for this reason, they may potentially be somewhat dangerous, as volition can be increased, possibly giving the patient a greater desire to attempt or commit suicide.
People who had moderate or severe digestive side effects were more likely to stop the medications. In severe cases, patients have sued drugmakers contending the medications led to lasting harms.