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Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. [4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. [4]
Statins are generally recommended for adults between the ages of 40 and 75 who have heart disease risk factors. Despite having higher risks for cardiovascular disease, fewer older adults use statins.
These create expectations of harm. Nocebo symptoms are real and bothersome and are a major barrier to treatment. Because of this, many people stop taking statins, [91] which have been proven in numerous large-scale RCTs to reduce heart attacks, stroke, and deaths [92] – as long as people continue to take them.
“Risk models don’t determine who is recommended to take statins, guidelines do,” Khan said. “I think the most important thing is the determination of when it will be recommended to ...
[22] [23] Another consequence of taking statins is the risk of developing new-onset diabetes, which is more prominent in individuals with high TG levels and body mass index (BMI). [19] However, the risk is far outweighed by the benefits from statin therapy for the reduction in cardiovascular outcomes. [20]
They also noted that many adults eligible to take statins based on PREVENT equations were not taking statins, equating to 15.8 million adults. New equations may impact how many people receive ...
With median follow-up of 6 years, simvastatin+ezetimibe was found to reduce the primary outcome of CV mortality, major CV event, or nonfatal stroke (34.7% vs. 32.7%; P=0.016; NNT 50 per 7 years or NNT 350 per 1 year ). There was no reduction in all-cause or CV mortality with simvastatin+ezetimibe, though there was a reduction in MI and stroke. [6]
Statins or other medications to treat high cholesterol levels. Medications to treat blood clots. If your doctor thinks that you’re at a high risk of developing complications, they may recommend ...