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Asbestos-related diseases are disorders of the lung and pleura caused by the inhalation of asbestos fibres. Asbestos-related diseases include non-malignant disorders such as asbestosis (pulmonary fibrosis due to asbestos), diffuse pleural thickening, pleural plaques, pleural effusion, rounded atelectasis and malignancies such as lung cancer and malignant mesothelioma.
The most common diseases associated with chronic exposure to asbestos are asbestosis and mesothelioma. [4] According to OSHA, [11] "there is no 'safe' level of asbestos exposure for any type of asbestos fiber. [12] [13] Asbestos exposures as short in duration as a few days have caused mesothelioma in humans. Every occupational exposure to ...
Pressure on the nerves can cause tingling sensations, numbness, pain, weakness, muscle atrophy and even paralysis of the affected area. In normal individuals, these symptoms disappear quickly, but in sufferers of HNPP even a short period of pressure can cause the symptoms to occur. Palsies can last from minutes or days to weeks or even months ...
The causes of nerve damage are grouped into categories including those due to paraneoplastic causes (neuropathy secondary to cancer), immune mediated, infectious, inherited or degenerative causes and those due to toxin exposure. In idiopathic sensory neuronopathy no cause is identified. Idiopathic causes account for about 50% of cases. [2]
The lack of family history does not rule out CMT but is helpful to rule out other causes of neuropathy, such as diabetes or exposure to certain chemicals or drugs. [45] In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined by sequencing the whole genome of an affected ...
Asbestos bodies in the absence of fibrosis indicate exposure, not disease. Figure A shows the location of the lungs, airways, pleura, and diaphragm in the body. Figure B shows lungs with asbestos-related diseases, including pleural plaque, lung cancer, asbestosis, plaque on the diaphragm, and mesothelioma.
A history of exposure to asbestos may increase clinical suspicion for mesothelioma. A physical examination is performed, followed by chest X-ray and often lung function tests. The X-ray may reveal pleural thickening commonly seen after asbestos exposure and increases suspicion of mesothelioma. [15] A CT (or CAT) scan or an MRI is usually performed.
Removal from exposure was the first line of treatment. Due to the progressive sensory loss and weakness, various medications were often required. These included intravenous methylprednisolone, oral prednisone, azathioprine, and/or IVIG. [7] All 24 patients improved, including 7 who received no treatment and 17 who required immunosuppressive ...
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