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The cause of multiple myeloma is unknown. [4] Risk factors include obesity, radiation exposure, family history, age and certain chemicals. [5] [11] [12] There is an increased risk of multiple myeloma in certain occupations. [13] This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple ...
MPNs arise when precursor cells (blast cells) of the myeloid lineages in the bone marrow develop somatic mutations which cause them to grow abnormally. There is a similar category of disease for the lymphoid lineage, the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma. [4]
Myelomalacia is a pathological term referring to the softening of the spinal cord. [1] Possible causes of myelomalacia include cervical myelopathy, hemorrhagic infarction, or acute injury, such as that caused by intervertebral disc extrusion.
Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of target organ manifestations such as kidney failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow. Bence Jones proteins are present in 2/3 of multiple myeloma cases. [3]
contact precautions final rev3: Author: Bob Hobbs: Software used: Adobe Illustrator CC 22.1 (Windows) Conversion program: Adobe PDF library 15.00: Encrypted: no: Page size: 612 x 792 pts (letter) Version of PDF format: 1.7
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