Ad
related to: ap 1 target genes and dna
Search results
Results From The WOW.Com Content Network
The AP-1 transcription factor also has been shown to be involved in breast cancer cell growth through multiple mechanisms, including regulation of cyclin D1, E2F factors and their target genes. c-Jun, which is one of the AP-1 subunits, regulates the growth of breast cancer cells.
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. [5] [6] [7] The Jun dimerization protein is a member of the AP-1 family of transcription factors. [5] JDP 2 was found by a Sos-recruitment system, [clarification needed] to dimerize with c-Jun to repress AP-1-mediated activation. [5]
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. [1] The AP-1 binding site, in humans, has a nucleotide sequence of ATGAGTCAT, where A corresponds to adenine, T corresponds to thymine, G corresponds to guanine, and C corresponds to cytosine.
In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage. It has been estimated that under physiological conditions 10,000 apurinic sites and 500 ...
[1] [2] [3] These DNA-binding domains are specific to a certain DNA sequence, allowing activators to turn on only certain genes. [1] [2] [3] Activation domains also come in a variety of types that are categorized based on the domain's amino acid sequence, including alanine-rich, glutamine-rich, and acidic domains. [1]
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. [1] [2] The function of TFs is to regulate—turn on and off—genes in order to make sure that they are ...
211556 Ensembl ENSG00000138660 ENSMUSG00000074238 UniProt Q63HQ0 n/a RefSeq (mRNA) NM_001128426 NM_018569 NM_145964 NM_001346718 RefSeq (protein) NP_001121898 NP_061039 n/a Location (UCSC) Chr 4: 112.23 – 112.27 Mb Chr 3: 127.6 – 127.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a ...