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The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Toxocariasis is a parasitic disease of the eye associated with exposure to infected puppies, which causes a retinal lesion leading to retinal detachment. 4. Retinopathy of prematurity is associated with low-birth-weight infants who receive supplemental oxygen in the period immediately after birth, and it involves damage to the retinal tissue ...
One physiological cause of fatigue is anemia, which can be caused by chemotherapy, surgery, radiotherapy, primary and metastatic disease or nutritional depletion. [ 95 ] [ 96 ] Aerobic exercise has been found to be beneficial in reducing fatigue in people with solid tumours .
Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, an apicomplexan. [3] Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. [ 8 ] Occasionally, people may have a few weeks or months of mild, flu-like illness such as muscle aches and tender lymph nodes . [ 1 ]
Safety concerns regarding the long term effects of chemotherapy remains a concern. Side effects of the VAC regimen include nausea, vomiting, liver damage, and immune system suppression. [36] The length and dosing of the chemotherapy is oftentimes on a case-by-case basis based on the person's stage of cancer, site of tumor and age.
Sensory side effects include paresthesias, dysesthesias, numbness, altered proprioception, and loss of dexterity in fingers and toes. Motor and autonomic symptoms are less frequent but possible. Symptoms may start days after the patient receives their first dose of chemotherapy, are dose dependent, and tend to improve after completion of treatment.
With multi-focal disease 60% have a chronic course, 30% achieve remission and mortality is up to 10%. [48] A full recovery can be expected for people who seek treatment and do not have more lesions at 12 and 24 months. However, 50% of children under 2 with disseminated Langerhans cell histiocytosis die of the disease.