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  2. Denosumab - Wikipedia

    en.wikipedia.org/wiki/Denosumab

    Denosumab, sold under the brand names Prolia among others, is a human monoclonal antibody used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. [11] [12] The most common side effects are joint and muscle pain in the arms or legs. [13]

  3. US FDA adds 'boxed warning' for Amgen's bone loss drug Prolia

    www.aol.com/news/us-fda-adds-boxed-warning...

    Prolia, approved in 2010 to treat bone loss in postmenopausal women and later approved to treat men and women at high risk of fracture, brought in total third-quarter sales of $986 million.

  4. Deprescribing - Wikipedia

    en.wikipedia.org/wiki/Deprescribing

    Deprescribing can improve adherence, cost, and health outcomes but may have adverse drug withdrawal effects. More specifically, deprescribing is the planned and supervised process of intentionally stopping a medication or reducing its dose to improve the person's health or reduce the risk of adverse side effects. Deprescribing is usually done ...

  5. Drug withdrawal - Wikipedia

    en.wikipedia.org/wiki/Drug_withdrawal

    The stopping of antidepressants for example, can lead to antidepressant discontinuation syndrome. With careful physician attention, however, medication prioritization and discontinuation can decrease costs, simplify prescription regimens, decrease risks of adverse drug events and poly-pharmacy, focus therapies where they are most effective, and ...

  6. Prolia: Is it covered by Medicare?

    www.aol.com/prolia-covered-medicare-010000191.html

    Prolia (denosumab) is an injectable medication that helps treat osteoporosis. Osteoporosis is a condition that causes the bones to become thin and weak, leading to a higher risk of fractures and ...

  7. Medication-related osteonecrosis of the jaw - Wikipedia

    en.wikipedia.org/wiki/Medication-related_osteo...

    Owing to prolonged embedding of bisphosphonate drugs in the bone tissues, the risk for MRONJ is elevated even after stopping the administration of the medication for several years. [ 25 ] Patients who stopped taking anti-angiogenic drugs are exposed to the same risk as patients who have never taken the drugs because anti-angiogenic drugs do not ...

  8. The top 7 mental health challenges of the holidays and how to ...

    www.aol.com/top-7-mental-health-challenges...

    As the song goes, it's the most wonderful time of the year. The holidays are expected to be a joyful, harmonious, and celebratory time of year… but for many, it can also bring a mix of emotional ...

  9. Antidepressant discontinuation syndrome - Wikipedia

    en.wikipedia.org/wiki/Antidepressant...

    Methods of prevention include gradually decreasing the dose among those who wish to stop, though it is possible for symptoms to occur with tapering. [2] [6] [4] Treatment may include restarting the medication and slowly decreasing the dose. [2] People may also be switched to the long-acting antidepressant fluoxetine which can then be gradually ...