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Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014 1 Adalimumab: Humira Biologic Rheumatoid arthritis: AbbVie Inc. 14,012 1,469 2 Ledipasvir/sofosbuvir: Harvoni Small molecule Hepatitis C: Gilead Sciences: 13,864 11,737 3 Etanercept: Enbrel Biologic Rheumatoid arthritis: Amgen. Pfizer. 8,697 4,009 4 Infliximab ...
Chimeric small molecule therapeutics are a class of drugs designed with multiple active domains to operate outside of the typical protein inhibition model. While most small molecule drugs inhibit target proteins by binding their active site, chimerics form protein-protein ternary structures to induce degradation or, less frequently, other protein modifications.
In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons [1]) organic compound that may regulate a biological process, with a size on the order of 1 nm [citation needed]. Many drugs are small molecules; the terms are equivalent in the literature.
Enantiopure drugs (136 P) Pages in category "Small-molecule drugs" The following 21 pages are in this category, out of 21 total.
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. Brand names and generic names are differentiated by capitalizing brand names. See also the list of the top 100 bestselling branded drugs, ranked by sales.
Two thirds of the active ingredients needed to make generic drugs are manufactured in Asia, a study showed on Wednesday, the latest evidence to underscore Europe's reliance on foreign imports for ...
molecules with drug-like properties "ChEMBL". 1,961,000 cheML.io: Departments of Computer Science and Chemistry at Nazarbayev University de novo molecules generated by ML models SMILES, computed properties artificially generated "cheML.io". [3] 2,800,000 ChemDB chemical database small molecules "ChemDB". 5,000,000 ChemExper Chemexper Chemical ...
According to a paper published in May 2021, of 10,000 promising compounds identified by researchers, only one or two antibiotic drugs reached US Food and Drug Administration approval.