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The scientists analyzed blood, urine, feces, and tissue samples and found three metabolites: 2,4-dihydroxybenzophenone (DHB), 2,2-dihydroxy-4-methoxybenzophenone (DHMB) and 2,3,4-trihydroxybenzophenone (THB). [28] [29] To form DHB the methoxy functional group undergoes O-dealkylation; to form THB the same ring is hydroxylated. [27]
4,4′-Dihydroxybenzophenone is prepared by the rearrangement of p-hydroxyphenylbenzoate: HOC 6 H 4 CO 2 C 6 H 5 → (HOC 6 H 4) 2 CO. Alternatively, p-hydroxybenzoic acid can be converted to p-acetoxybenzoyl chloride. This acid chloride reacts with phenol to give, after deacetylation, 4,4′-dihydroxybenzophenone.
There are three structural isomers: 1,2-dihydroxybenzene (the ortho isomer) is commonly known as catechol, 1,3-dihydroxybenzene (the meta isomer) is commonly known as resorcinol, and 1,4-dihydroxybenzene (the para isomer) is commonly known as hydroquinone.
2,4-Dihydroxybenzoic acid (β-resorcylic acid) is a dihydroxybenzoic acid. As a resorcylic acid, it is one of the three isomeric crystalline acids that are both carboxyl derivatives of resorcinol and dihydroxy derivatives of benzoic acid. [4] Synthesis from resorcinol is via the Kolbe-Schmitt reaction. [5]
Benzophenone is a naturally occurring organic compound with the formula (C 6 H 5) 2 CO, generally abbreviated Ph 2 CO. Benzophenone has been found in some fungi, fruits and plants, including grapes. [4] It is a white solid with a low melting point and rose-like odor [5] that is soluble in organic solvents. Benzophenone is the simplest ...
In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. [1] [2] When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Among the various properties of ...
4,4’-Difluorobenzophenone is an organic compound with the formula of (FC 6 H 4) 2 CO. This colorless solid is commonly used as a precursor to PEEK, or polyetherether ketone, a so-called high performance polymer. Because PEEK is resistant to attack, it is commonly used in carbon fiber coatings and cable insulation.
BPA binding to ERR-γ preserves its basal constitutive activity. [92] It can also protect it from deactivation from the SERM 4-hydroxytamoxifen (afimoxifene). [92] This may be the mechanism by which BPA acts as a xenoestrogen. [92] Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects.