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Alanine transaminase (ALT), also known as alanine aminotransferase (ALT or ALAT), formerly serum glutamate-pyruvate transaminase (GPT) or serum glutamic-pyruvic transaminase (SGPT), is a transaminase enzyme (EC 2.6.1.2) that was first characterized in the mid-1950s by Arthur Karmen and colleagues. [1]
108682 Ensembl ENSG00000166123 ENSMUSG00000031700 UniProt Q8TD30 Q8BGT5 RefSeq (mRNA) NM_133443 NM_001142466 NM_173866 RefSeq (protein) NP_001135938 NP_597700 NP_776291 Location (UCSC) Chr 16: 46.88 – 46.93 Mb Chr 8: 86.22 – 86.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutamic--pyruvic transaminase 2 is a protein that in humans is encoded by the GPT2 gene. Function This ...
In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver dysfunction. [1] [2] Other terms include transaminasemia, [3] and elevated liver enzymes (though they are not the only enzymes in the liver).
The specific enzymes are named from one of the reactant pairs, for example; the reaction between glutamic acid and pyruvic acid to make alpha ketoglutaric acid and alanine is called alanine transaminase and was originally called glutamic-pyruvic transaminase or GPT for short. [1]
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
The liver transaminases aspartate transaminase (AST or SGOT) and alanine transaminase (ALT or SGPT) are useful biomarkers of liver injury in a patient with some degree of intact liver function. [2] [3] [4] Most liver diseases cause only mild symptoms initially, but these diseases must be detected early. Hepatic (liver) involvement in some ...
Excerpts of body-worn camera footage from four corrections officers were released Friday by the New York Attorney General’s Office showing the in-custody beating of 43-year-old inmate Robert ...
Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. [1] The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma , a monoclonal gammopathy of uncertain significance (MGUS), or further investigate a discrepancy ...