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The Age-Related Eye Disease Study (AREDS) was a clinical trial sponsored by the National Eye Institute that ran from 1992 to 2001. [1] The study was designed to: investigate the natural history and risk factors of age-related macular degeneration (AMD) and cataracts , and
The specific vitamins and minerals in AREDS-1 are vitamin C (500 mg), zinc (80 mg), vitamin E (400 IU), copper (2 mg) and beta-carotene (15 mg). In the AREDS-2 formulation, lutein (10 mg) and zeaxanthin (2 mg) replaced beta-carotene due to the risk of lung cancer in smokers taking beta-carotene. [ 2 ]
Lutein (/ ˈ lj uː t i ɪ n,-t iː n /; [2] from Latin luteus meaning "yellow") is a xanthophyll and one of 600 known naturally occurring carotenoids.Lutein is synthesized only by plants, and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots.
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