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Thus, the genotype most at risk for Alzheimer's disease and at an earlier age is APOE4,4. Using genotype APOE3,3 as a benchmark (with the persons who have this genotype regarded as having a risk level of 1.0) and for white populations only, individuals with genotype APOE4,4 have an odds ratio of 14.9 of developing Alzheimer's disease ...
“The APOE-e4 allele is the most important for Alzheimer’s disease risk,” she continued.“About 25% of people in the U.S. have at least one APOE-e4 allele and about 5% have two copies of it ...
All participants were also tested for the ApoE gene, which, when present, increases one’s risk for Alzheimer’s disease. Of the 859 participants, ...
[16] [19] APOE 𝜀4 is the most common risk factor for LOAD, increasing genetic risk up to 33-fold, depending on the population (see the table below). [20] Over 50% of LOAD patients have the 𝜀4 allele and that having even one copy of the 𝜀4 allele increases the risk of developing Alzheimer's by a factor of 4.
In a second analysis, they also adjusted for medical factors, including hypertension, diabetes mellitus, APOE e4 allele (which increases dementia risk), body mass index (BMI), cholesterol levels ...
But Alzheimer’s most commonly strikes after 65, especially in the late 70s to 80s, and the APOE gene – which also affects how the body handles fats -- was long known to play some role. There are three main varieties. Most people carry the APOE3 variant that appears to neither increase nor decrease Alzheimer’s risk.