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Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. [5] It is encoded in humans by the gene APOE. Apo-E belongs to a family of fat-binding proteins called apolipoproteins.
ApoE is the major lipoprotein in the central nervous system. Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related. [ 8 ]
APOE associates with high-density lipoproteins (HDL). [12] The gene for APOE is located on chromosome 19 and exhibits polymorphisms in the population defined by three alleles of APOE: 𝜀2, 𝜀3, and 𝜀4. [16] [19] These alleles differ by only two single nucleotide polymorphisms in exon 4, rs429358 and rs7412 (amino-acid position 112 and 158).
The ApoE4 genetic variant is associated with the highest risk, while a rare form, ApoE Christchurch, binds weakly to HSPGs and appears to reduce the risk of Alzheimer’s in genetically ...
And older adults with a particular gene – apolipoprotein E, or APOE, which is involved with the process of carrying cholesterol and other fat through the bloodstream – are also at higher risk ...
This included age, sex, education level, marital status, brain size, and APOE-E4 status — a gene associated with dementia. During an average follow-up of 5.8 years, they found that those with a ...
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