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In science, ex vivo refers to experimentation or measurements done in or on tissue from an organism in an external environment with minimal alteration of natural conditions. [ 2 ] A primary advantage of using ex vivo tissues is the ability to perform tests or measurements that would otherwise not be possible or ethical in living subjects.
Mice are the most commonly used mammal species for live animal research. Such research is sometimes described as vivisection. Vivisection (from Latin vivus 'alive' and sectio 'cutting') is surgery conducted for experimental purposes on a living organism, typically animals with a central nervous system, to view living internal structure.
However, ex vivo gene therapies are better tolerated and less associated with severe immune responses. [63] The death of Jesse Gelsinger in a trial of an adenovirus -vectored treatment for ornithine transcarbamylase deficiency due to a systemic inflammatory reaction led to a temporary halt on gene therapy trials across the United States. [ 64 ]
Edward H. Hagen writes in The Handbook of Evolutionary Psychology that sociobiology is, despite the public controversy regarding the applications to humans, "one of the scientific triumphs of the twentieth century." "Sociobiology is now part of the core research and curriculum of virtually all biology departments, and it is a foundation of the ...
Sociobiology: The New Synthesis (1975; 25th anniversary edition 2000) is a book by the biologist E. O. Wilson.It helped start the sociobiology debate, one of the great scientific controversies in biology of the 20th century and part of the wider debate about evolutionary psychology and the modern synthesis of evolutionary biology.
Wilhelm T. Preyer, a pioneer of child psychology, was heavily inspired by Darwin's work and approached the mental development of children from an evolutionary perspective. [14] However, evolutionary theory has had a limited impact on developmental psychology as a whole, [5] and some authors argue that even its early influence was minimal. [15]
Two methods of gene therapy using lentiviruses have been proposed. In the ex vivo methodology, cells are extracted from a patient and then cultured. A lentiviral vector carrying therapeutic transgenes are then introduced to the culture to infect them. The now modified cells continue to be cultured until they can be infused into the patient.
Complex systems biology is a field of science that studies the emergence of complexity in functional organisms from the viewpoint of dynamic systems theory. [20] The latter is also often called systems biology and aims to understand the most fundamental aspects of life.