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The hazard ratio is the effect on this hazard rate of a difference, such as group membership (for example, treatment or control, male or female), as estimated by regression models that treat the logarithm of the HR as a function of a baseline hazard () and a linear combination of explanatory variables:
The relative risk (RR) or risk ratio is the ratio of the probability of an outcome in an exposed group to the probability of an outcome in an unexposed group. Together with risk difference and odds ratio , relative risk measures the association between the exposure and the outcome.
In epidemiology, a rate ratio, sometimes called an incidence density ratio or incidence rate ratio, is a relative difference measure used to compare the incidence rates of events occurring at any given point in time. It is defined as:
It is computed as , where is the incidence in the exposed group, and is the incidence in the unexposed group. If the risk of an outcome is increased by the exposure, the term absolute risk increase (ARI) is used, and computed as I e − I u {\displaystyle I_{e}-I_{u}} .
The hazard rate at time is the probability per short time dt that an event will occur between and + given that up to time no event has occurred yet. For example, taking a drug may halve one's hazard rate for a stroke occurring, or, changing the material from which a manufactured component is constructed, may double its hazard rate for failure.
It is computed as () /, where is the incidence in the exposed group, and is the incidence in the unexposed group. If the risk of an adverse event is increased by the exposure rather than decreased, the term relative risk increase (RRI) is used, and it is computed as ( I e − I u ) / I u {\displaystyle (I_{e}-I_{u})/I_{u}} .
It is defined as the inverse of the absolute risk increase, and computed as / (), where is the incidence in the treated (exposed) group, and is the incidence in the control (unexposed) group. [1] Intuitively, the lower the number needed to harm, the worse the risk factor, with 1 meaning that every exposed person is harmed.
It is calculated as = / = /, where is the incidence in the exposed group, is the incidence in the unexposed group, and is the relative risk. [2] It is used when an exposure increases the risk, as opposed to reducing it, in which case its symmetrical notion is preventable fraction among the unexposed .