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For example, the fourth generation of cephalosporins is not recognized as such in Japan. [citation needed] In Japan, cefaclor is classed as a first-generation cephalosporin, though in the United States it is a second-generation one; and cefbuperazone, cefminox, and cefotetan are classed as second-generation cephalosporins.
Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics. It was patented in 1974 and approved for medical use in 1981. [1]
Cephalosporin C is the product of the biosynthesis pathway of third generation cephalosporins. This is done by exchanging the acetyl CoA into DAC. [4] To achieve cephalosporin C as the end product, there are 6 genes reported to be in control of the pathway. [4]
Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [4] These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. [4]
Cefcapene is a third-generation cephalosporin antibiotic. It was patented in 1985 and approved for medical use in 1997. [1] References This page ...
Ceftazidime, sold under the brand name Fortaz among others, is a third-generation cephalosporin antibiotic useful for the treatment of a number of bacterial infections. [1] [5] Specifically it is used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, Pseudomonas aeruginosa infection, and vibrio infection. [1]
Some of the third generation drugs can be absorbed orally without the need of esterification. This is for example done with cefixime and cefdinir by putting a vinyl group in the C-3 position. [5] [9] Examples of 3rd generation cephalosporins: A) cefdinir; B) cefixime; C) ceftibuten
It is a third-generation cephalosporin and works by interfering with a bacteria's ability to make a cell wall resulting in its death. [1] It was patented in 1979 and approved for medical use in 1991. [3] It is available as a generic medication. [1]