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A 2015 Cochrane review found that intra-articular corticosteroid injections of the knee did not benefit quality of life and had no effect on knee joint space; clinical effects one to six weeks after injection could not be determined clearly due to poor study quality. [11]
Radiosynoviorthesis involves the intra-articular injection of radioactive isotopes to specifically treat the inflamed synovial membrane. Synovitis, a hallmark of various joint disorders, including osteoarthritis, manifests as inflammation within the synovial membrane lining the joints.
Synoviorthesis, or medical synovectomy, may be achieved with the intra-articular injection of several substances: [5] Osmic acid, [6] rifampicin and rifamycin (i.e. chemosynovectomy) Yttrium-90, erbium-169, dysprosium-165 and rhenium-186 [7] (radiosynovectomy)
“During the treatment process, a physician might decide that corticosteroid injection into an affected joint is warranted. This is referred to as an ‘intra-articular’ joint injection.
In 1986, sodium hyaluronate was used as an intra-articular injection to treat osteoarthritis of the knee with the product Hyalart/Hyalgan by Fidia of Italy. [ 27 ] See also
Since the joint capsule is relatively well contained, intra-articular injections are highly successful at delivering the therapeutic gene therapy locally to the target cell types. Treatment of osteoarthritis may be successful via: Stimulation of anabolic pathways to rebuild the matrix or chondrocyte content of cartilage.