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Because of the potential for more severe side effects, this drug is on the list to avoid in the elderly. [22] In many countries (including the US and UK), promethazine is contraindicated in children less than two years of age, and strongly cautioned against in children between two and six, due to problems with respiratory depression and sleep ...
It is delivered subcutaneously either by injection or from an insulin pump. [5] [6] Onset of effects typically occurs within 30 minutes and lasts about 5 hours. [5] Often a longer-acting insulin like insulin NPH is also needed. [5] Common side effects include low blood sugar. [5] Other serious side effects may include low blood potassium. [5]
The results were essentially the same in relief and discharge ratings but chlorpromazine was safer with fewer side-effects, easier to administer, and better suited to long-term care. [citation needed] In 1958, Bourne published a paper on increasing disillusionment in the psychiatric literature about insulin coma therapy for schizophrenia.
The maximum dose is used, rather than a lower dose, to reduce the number of test subjects (and, among other things, the cost of testing), to detect an effect that might occur only rarely. This type of analysis is also used in establishing chemical residue tolerances in foods. Maximum tolerated dose studies are also done in clinical trials.
The unit of insulin was set by the insulin committee at the University of Toronto. [53] The unit evolved eventually to the old USP insulin unit, where one unit (U) of insulin was set equal to the amount of insulin required to reduce the concentration of blood glucose in a fasting rabbit to 45 m g/d L (2.5 m mol/L). Once the chemical structure ...
The common side effect is low blood sugar. [5] Other side effects may include pain or skin changes at the sites of injection, low blood potassium, and allergic reactions. [5] Use during pregnancy is relatively safe for the baby. [5] Regular insulin can be made from the pancreas of pigs or cows. [2]
Short term drug side effects are most likely to occur at or near the C max, whereas the therapeutic effect of drug with sustained duration of action usually occurs at concentrations slightly above the C min. [citation needed] The C max is often measured in an effort to show bioequivalence (BE) between a generic and innovator drug product. [4]
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