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This is a complete list of estrogens and formulations that are approved by the FDA Tooltip Food and Drug Administration and available in the United States. Estrogens are used as hormonal contraceptives , in hormone replacement therapy , and in the treatment of gynecological disorders .
Oral progesterone is micronized (ground) to increase availability and is approved by the FDA to treat endometrial hyperplasia when used in opposition to estrogen. It has also been approved to relieve menopausal symptoms, either alone or in combination with estrogen. It is more reliable in treating menopausal sleep disorders than synthetic ...
Estetrol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. [ 2 ] [ 3 ] Due to its estrogenic activity, estetrol has antigonadotropic effects and can inhibit fertility and suppress sex hormone production and levels in both women and men.
[9] [8] As such, it is an estrogen, or an agonist of the estrogen receptors. [8] [9] Estradiol acetate is of about 15% higher molecular weight than estradiol due to the presence of its C3 acetate ester. [3] Because estradiol acetate is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen. [9] [10]
Sivifene (A-007) was initially thought to be a SERM due to its structural similarity to tamoxifen but it was subsequently found not to bind to the estrogen receptor (ER). [8] Tesmilifene (DPPE; YMB-1002, BMS-217380-01) is also structurally related to tamoxifen but similarly does not bind to the ER and is not a SERM.
[14] [8] Estradiol cypionate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [8] [7] Estradiol cypionate is an estrogen ester and a long-lasting prodrug of estradiol in the body. [14] [8] [7] Because of this, it is considered to be a natural and bioidentical form of estrogen ...