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Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Eye disease: JIA is associated with inflammation in the front of the eye (specifically iridocyclitis, a form of chronic anterior uveitis), which affects about one in six children with JIA. Eye involvement occurs most commonly in girls, those with only a few joints involved ( oligoarthritis ), and those with a positive anti-nuclear antibody (ANA ...
The blood–ocular barrier is a barrier created by endothelium of capillaries of the retina and iris, ciliary epithelium and retinal pigment epithelium. [1] It is a physical barrier between the local blood vessels and most parts of the eye itself, and stops many substances including drugs from traveling across it. [2]
Rheumatoid arthritis (RA) is a disorder in which the body's own immune system starts to attack body tissues specifically the cartilage at the end of bones known as articular cartilage. [76] The attack is not only directed at the joint but to many other parts of the body.
An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body. There are many diseases known to cause ocular or visual changes.
Diabetic retinopathy, eye damage that frequently occurs as a result of diabetes, is related to the breakdown of the blood–retinal barrier. [4] The barrier becomes more leaky in patients with diabetic retinopathy.
Diagram of a human eye (horizontal section of the right eye) 1. Lens, 2. Zonule of Zinn or Ciliary zonule, 3. Posterior chamber and 4. Anterior chamber with 5. Aqueous humour flow; 6. Pupil, 7. Corneosclera or Fibrous tunic with 8. Cornea, 9. Trabecular meshwork and Schlemm's canal. 10. Corneal limbus and 11. Sclera; 12. Conjunctiva, 13. Uvea ...
This junction marks the transition from the simple, non-photosensitive area of the ciliary body to the complex, multi-layered, photosensitive region of the retina. The pigmented layer is continuous over choroid, ciliary body and iris while the nervous layer terminates just before the ciliary body. This point is the ora serrata.