Search results
Results From The WOW.Com Content Network
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic ...
5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene that codes for the serotonin transporter. Since the polymorphism was identified in the middle of the 1990s, [ 1 ] [ 2 ] it has been extensively investigated, e.g., in connection with ...
A 2003 study proposed that a gene-environment interaction (GxE) may explain why life stress is a predictor for depressive episodes in some individuals, but not in others, depending on an allelic variation of the serotonin-transporter-linked promoter region . [15]
It has been observed that the pathology of depression involves dysfunction of monoamine neurotransmitter circuits in the CNS, particularly of serotonin and norepinephrine. Selective serotonin reuptake inhibitors (SSRIs) are the most widely used antidepressant and include fluoxetine (Prozac), citalopram (Celexa), and fluvoxamine (Luvox). These ...
The findings of this study have then been replicated by researchers like Kendler et al. (2005) who showed children experiencing maltreatment and carried the 5HTTLPR gene displayed increased sensitivity to severe depression as adults, [22] Vrshek-Schallhorn et al. (2014) who displayed the interaction between stressful life events and the 5HTTLPR ...
5-Hydroxytryptamine receptor 2B (5-HT 2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene. [ 5 ] [ 6 ] 5-HT 2B is a member of the 5-HT 2 receptor family that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
Epigenetics of depression is the study of how epigenetics (heritable characteristics that do not involve changes in DNA sequence) contribute to depression. Major depressive disorder is heavily influenced by environmental and genetic factors.
Increased methylation of the 5-HTT transporter and 5-HTR1A receptor genes of the serotonergic system were observed in individuals with bipolar disorder. [4] The 5-HTT transporter is responsible for the reuptake of serotonin from the synaptic cleft back into the presynaptic cell after initial release.