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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
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Paraneoplastic pemphigus (PNP) is an autoimmune disorder stemming from an underlying tumor. It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes .
Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus.Pemphigus was derived from the Greek word pemphix, meaning blister. [1] It is classified as a type II hypersensitivity reaction in which antibodies are formed against desmosomes, components of the skin that function to keep certain layers of skin bound to each other.
[17] [18] Currently rituximab is considered a first-line treatment for some pemphigus patients according to Delphi consensus recommendations [19] All of these drugs may cause severe side effects, so patients should be closely monitored by doctors. Once the outbreaks are under control, dosage is often reduced, to lessen side effects.
The selection and use of essential medicines: report of the WHO Expert Committee, 2017 (including the 20th WHO Model List of Essential Medicines and the 6th Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl: 10665/259481. ISBN 978-92-4-121015-7. ISSN 0512-3054. WHO technical report series; no. 1006.
Drug-induced pemphigus: IgG: Desmoglein 3 Desmoglein 1: 130 160 Subcorneal pustular dermatosis type of IgA pemphigus: IgA1: Desmocollin 1: 110/100 Intraepidermal neutrophilic type of IgA pemphigus: IgA1: Unknown: Pemphigus erythematosus (Senear–Usher syndrome) [nb 3] IgG: Desmoglein 1: 160 Fogo selvagem: IgG: Desmoglein 1: 160 Pemphigus ...
Very rarely seen in children, bullous and non-bullous pemphigoid most commonly occurs in people 70 years of age and older. [2] Its estimated frequency is seven to 14 cases per million per year, but has been reported to be as high as 472 cases per million per year in Scottish men older than 85. [2]