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The synthesis of clonazolam was first reported in 1971 and the drug was described as the most active compound in the series tested. [7] Depending on dose consumed, clonazolam may pose comparatively higher risk than other designer benzodiazepines due to its ability to produce strong sedation and amnesia at doses as small as 0.5 mg. [2] [8]
Metabolic pathway of cloniprazepam. Cloniprazepam is a benzodiazepine derivative and a prodrug of clonazepam, 7-aminoclonazepam, and other metabolites. [1] [2]Some of the minor metabolites include 3-hydroxyclonazepam and 6-hydroxyclonazepam, 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.
Phenazolam, (Clobromazolam, DM-II-90, BRN 4550445) is a benzodiazepine derivative which acts as a potent sedative and hypnotic drug. It was first invented in the early 1980s, [1] but was never developed for medical use.
In 2024, amidst a record 27-year high inflation rate of 28.92% and a significant decline in the value of the Naira, [35] the cost of antibiotics witnessed a more than tenfold increase in price. [36] Other medicines, such as asthma inhalers and diabetic medications, were also significantly affected.
A sign adorns a Billabong store in Sydney' s CBD on August 28, 2014, as the embattled Australian surfwear firm posted a 218.2 million USD net annual loss.
Nitrazolam is a triazolobenzodiazepine (TBZD) , which are benzodiazepine (BZD) derivatives, [1] that has been sold online as a designer drug. [2] [3]It is closely related to clonazolam or flunitrazolam, only differing by the removal of a chlorine or fluorine group respectively at the benzene ring.
We tracked down the week's best deals at Amazon, including an iPad that's $100 off and a range of beauty products that are marked down.
Flunitrazolam (FNTZ, Flunazolam) is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug, and is a potent hypnotic and sedative drug similar to related compounds such as flunitrazepam, clonazolam and flubromazolam.