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6915 21390 Ensembl ENSG00000006638 ENSMUSG00000034881 UniProt P21731 P30987 RefSeq (mRNA) NM_001060 NM_201636 NM_001277265 NM_009325 NM_001358512 RefSeq (protein) NP_001051 NP_963998 NP_001264194 NP_033351 NP_001345441 Location (UCSC) Chr 19: 3.59 – 3.61 Mb Chr 10: 81.16 – 81.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The thromboxane receptor (TP) also known as the ...
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. [2]
Granulocyte-macrophage colony-stimulating factor and granulocyte CSF are given to stimulate white blood cell formation in cancer patients who are receiving chemotherapy, which tends to kill their red bone marrow cells as well as the cancer cells. Thrombopoietin shows great promise for preventing platelet depletion during chemotherapy. CSFs and ...
Platelets secrete thromboxane A2, which acts on the platelet's own thromboxane receptors on the platelet surface (hence the so-called "out-in" mechanism), and those of other platelets. These receptors trigger intraplatelet signaling, which converts GPIIb/IIIa receptors to their active form to initiate aggregation .
Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs .
Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. [5] Megakaryocytopoiesis is the cellular development process that leads to platelet production.