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Allantoin is a chemical compound with formula C 4 H 6 N 4 O 3. It is also called 5-ureidohydantoin or glyoxyldiureide . [ 1 ] [ 2 ] It is a diureide of glyoxylic acid .
Rasburicase, sold under the brand name Elitek in the US and Fasturtec in the EU, is a medication that helps to clear uric acid from the blood.It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin.
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Pegloticase is a PEGylated recombinant porcine-like uricase.Similarly to rasburicase, it metabolises uric acid to allantoin.This reduces the risk of urate precipitates, since allantoin is five to ten times more soluble than uric acid.
Imidazolidinyl urea is produced by the chemical reaction of allantoin and formaldehyde in the presence of sodium hydroxide solution and heat. The reaction mixture is then neutralized with hydrochloric acid and evaporated: 2 + 3 H 2 C=O →
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