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Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins (atypical proteins in the blood) that become insoluble at low temperatures. [1] Cryoglobulinemia is also one of three types in its own family. Type two is when there are two types of atypical proteins in the bloodstream, monoclonal and polyclonal.
Cryoglobulinemic vasculitis is a form of inflammation affecting the blood vessels caused by the deposition of abnormal proteins called cryoglobulins.These immunoglobulin proteins are soluble at normal body temperatures, but become insoluble below 37 °C (98.6 °F) and subsequently may aggregate within smaller blood vessels.
Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder.These pathological cold sensitive antibodies include cold agglutinins, Donath–Landsteiner antibodies, and cryoglobulins which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath ...
Cryoglobulinemia: Triad of Reactive arthritis: Urethritis, conjunctivitis and anterior uveitis, arthritis: Reactive arthritis: Saint's Triad: Gall stones, Diverticulosis, Hiatus hernia: Samter's triad (also known as Acetylsalicylic acid triad or Widal's triad [citation needed] or Francis' triad [citation needed] or Aspirin triad)
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma ...
Many cases of cryoglobulinemia vasculitis are asymptomatic. [27] Hyperviscosity and/or thrombosis are the principal signs and symptoms of type I cryoglobulinemia . As a result, the conditions most frequently manifested as Raynaud's phenomenon , distal gangrene , ischemic ulcers, purpura , livedo reticularis , headache , retinal hemorrhages, and ...
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Inflammation-induced damage to the skin's blood vessels causes palpable purpura. Palpable purpura is the clinical manifestation of leukocytoclastic vasculitis, which can be idiopathic or linked to sepsis, reactions to drugs, connective tissue diseases, cryoglobulinemia, hepatitis C or B infection, or underlying cancers