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  2. Platelet - Wikipedia

    en.wikipedia.org/wiki/Platelet

    Platelets are either isolated from collected units of whole blood and pooled to make a therapeutic dose, or collected by platelet apheresis: blood is taken from the donor, passed through a device which removes the platelets, and the remainder is returned to the donor in a closed loop. The industry standard is for platelets to be tested for ...

  3. Thrombopoiesis - Wikipedia

    en.wikipedia.org/wiki/Thrombopoiesis

    Platelets are regulators of hemostasis and thrombosis. Platelets become active in the blood following vascular injury. Vascular injury causes platelets to stick to the cellular matrix that is exposed under the endothelium, form a platelet plug, and then form a thrombus. Platelets are essential in the formation of an occlusive thrombus and are ...

  4. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial platelet tissue factor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis.

  5. Plateletpheresis - Wikipedia

    en.wikipedia.org/wiki/Plateletpheresis

    Platelets collected by using apheresis at an American Red Cross donation center. Not all platelet transfusions use platelets collected by automated apheresis. The platelets can also be separated from donations of whole blood collected in a traditional blood donation, but there are several advantages to separating the platelets at the time of collection.

  6. Platelet transfusion - Wikipedia

    en.wikipedia.org/wiki/Platelet_transfusion

    An ageing population, an increase in the number of people with blood cancer, and changes to the management of these cancers are likely the major reasons for the rise in demand for platelets. [27] Since 1990, the number of stem cell transplants performed in Europe has risen from 4,200 to over 40,000 annually.

  7. Platelet concentrate - Wikipedia

    en.wikipedia.org/wiki/Platelet_concentrate

    Originally, platelets were stored in the donor’s own plasma. Nowadays, many blood banks have switched to using platelet additive solution to store platelets. Typically, when platelets are isolated from whole blood, not all plasma is removed, as platelets need to be in a certain volume of plasma in order to have a clear separation from other ...

  8. Hemostasis - Wikipedia

    en.wikipedia.org/wiki/Hemostasis

    Aggregation of thrombocytes (platelets). Platelet-rich human blood plasma (left vial) is a turbid liquid. Upon addition of ADP, platelets are activated and start to aggregate, forming white flakes (right vial). Hemostasis occurs when blood is present outside of the body or blood vessels.

  9. Thromboregulation - Wikipedia

    en.wikipedia.org/wiki/Thromboregulation

    Thromboregulation is the series of mechanisms in how a primary clot is regulated. These mechanisms include, competitive inhibition or negative feedback. It includes primary hemostasis, which is the process of how blood platelets adhere to the endothelium of an injured blood vessel.

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