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[2] [3] Coronary artery ectasia occurs 4 times more frequently in males than in females and in people who have risk factors for heart disease such as smokers. [1] [4] [5] While the disease is commonly found in patients with atherosclerosis and coronary artery disease, it can occur by itself and in both cases, it can cause health problems.
For most people, the first symptoms result from atheroma progression within the heart arteries, most commonly resulting in a heart attack and ensuing debility. The heart arteries are difficult to track because they are small (from about 5 mm down to microscopic), they are hidden deep within the chest and they never stop moving.
Diagnosis of arteritis is based on unusual medical symptoms. [4] Similar symptoms may be caused by a number of other conditions, such as Ehlers-Danlos syndrome and Marfan syndrome (both heritable disorders of connective tissue), tuberculosis, syphilis, spondyloarthropathies, Cogans' syndrome, Buerger's, Behcet's, and Kawasaki disease. [4]
Fibrinoid necrosis is a pathological lesion that affects blood vessels, and is characterized by the occurrence of endothelial damage, followed by leakage of plasma proteins, including fibrinogen, from the vessel lumen; these proteins infiltrate and deposit within the vessel walls, where fibrin polymerization subsequently ensues.
Main symptoms Primary large vessel vasculitis [8] Takayasu arteritis: Diminished or absent pulses, vascular bruits, hypertension, Takayasu retinopathy, and aortic regurgitation. [9] Giant cell arteritis: Headache, scalp tenderness, jaw claudication, and blindness. [10] Primary medium vessel vasculitis [8] Polyarteritis nodosa
Coronary artery disease (CAD) or ischemic heart disease are the terms used to describe narrowing of the coronary arteries. [8] As the disease progresses, plaque buildup can partially block blood flow to the heart muscle. Without enough blood supply , the heart is unable to work properly, especially under increased stress.