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Tretinoin was patented in 1957 and approved for medical use in 1962. [13] It is on the World Health Organization's List of Essential Medicines. [14] Tretinoin is available as a generic medication. [15] In 2022, it was the 238th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [16] [17]
Kligman formula consisting of 0.1% tretinoin, 5.0% hydroquinone, 0.1% dexamethasone, and hydrophilic ointment. [12] The dermatologist gold-standard formula for treating hyperpigmentation is the Kligman formula, a prescription named after its inventor, dermatologist Dr. Albert Kligman. It was originally formulated in 1975 and has remained the ...
Acuity is a measure of visual performance and does not relate to the eyeglass prescription required to correct vision. Instead, an eye exam seeks to find the prescription that will provide the best corrected visual performance achievable. The resulting acuity may be greater or less than 6/6 = 1.0.
In this example the first eye, with a −1.00 diopter prescription, is the stronger eye, needing only slight correction to sharpen the image formed, and hence a thin spectacle lens. The second eye, with a −4.00 diopter prescription, is the weaker eye, needing moderate correction to sharpen the image formed, and hence a moderately thick ...
Tretinoin is the least expensive of the topical retinoids and is the most irritating to the skin, whereas adapalene is the least irritating but costs significantly more. [1] [100] Most formulations of tretinoin are incompatible for use with benzoyl peroxide. [15]
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2]