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Magnetic nanoparticles can also be used in conjunction with imaging modalities like ultrasound to improve imaging. [9] The use of nanoparticles in ophthalmic drug delivery is also being explored in clinical research. Magnetic nanoparticles inserted into rats' corneas or administered in an eye drop solution showed high adhesion to the target ...
Magnetite has an inverse spinel structure with oxygen forming a face-centered cubic crystal system. In magnetite, all tetrahedral sites are occupied by Fe 3+ and octahedral sites are occupied by both Fe 3+ and Fe 2+. Maghemite differs from magnetite in that all or most of the iron is in the trivalent state (Fe 3+
Ferrite nanoparticles or iron oxide nanoparticles (iron oxides in crystal structure of maghemite or magnetite) are the most explored magnetic nanoparticles up to date.Once the ferrite particles become smaller than 128 nm [22] they become superparamagnetic which prevents self agglomeration since they exhibit their magnetic behavior only when an external magnetic field is applied.
Magnetofection is a transfection method that uses magnetic fields to concentrate particles containing vectors to target cells in the body. [1] Magnetofection has been adapted to a variety of vectors, including nucleic acids, non-viral transfection systems, and viruses.
With the aid of nanoparticle delivery systems, however, studies have shown that some drugs can now cross the BBB, and even exhibit lower toxicity and decrease adverse effects throughout the body. Toxicity is an important concept for pharmacology because high toxicity levels in the body could be detrimental to the patient by affecting other ...
Another system of drug delivery involving nanoparticles is the use of aquasomes, self-assembled nanoparticles with a nanocrystalline center, a coating made of a polyhydroxyl oligomer, covered in the desired drug, which protects it from dehydration and conformational change.
The soapy surfactants used to coat the nanoparticles include, but are not limited to: oleic acid; tetramethylammonium hydroxide; citric acid; soy lecithin; These surfactants prevent the nanoparticles from clumping together, so the particles can not fall out of suspension nor clump into a pile of magnetic dust on near the magnet. The magnetic ...
Gated systems in cancer therapy also have the added effect of reducing off target effects and decreasing leakage and delivery of drug to normal tissues. Another use for this technology could also be antibacterial regulation. These systems could be used to limit bacterial resistance as well as accumulation of antibiotics within the body.