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Sodium thiosulfate is used in the treatment of cyanide poisoning. [3] It is on the World Health Organization's List of Essential Medicines. [4] [5] Other uses include topical treatment of ringworm and tinea versicolor, [3] [6] and treating some side effects of hemodialysis [7] and chemotherapy.
Sodium thiosulfate is a classical antidote to cyanide poisoning, [10] For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases. [4] [6] It is given by injection into a vein. [4] In this use, sodium nitrite creates methemoglobinemia which removes cyanide from mitochondria. [6]
Thiosulfate (IUPAC-recommended spelling; sometimes thiosulphate in British English) is an oxyanion of sulfur with the chemical formula S 2 O 2− 3.Thiosulfate also refers to the compounds containing this anion, which are the salts of thiosulfuric acid, such as sodium thiosulfate Na 2 S 2 O 3 and ammonium thiosulfate (NH 4) 2 S 2 O 3.
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
Sodium nitrite/sodium thiosulfate, sold under the brand name Nithiodote, is a fixed-dose combination medication used as an antidote for cyanide poisoning. [1] It contains sodium thiosulfate and sodium nitrite. [1] It is given by intravenous infusion into a vein. [1] It was approved for medical use in the United States in January 2011. [2]
This clock reaction uses sodium, potassium or ammonium persulfate to oxidize iodide ions to iodine. Sodium thiosulfate is used to reduce iodine back to iodide before the iodine can complex with the starch to form the characteristic blue-black color. Iodine is generated: 2 I − + S 2 O 2− 8 → I 2 + 2 SO 2− 4. And is then removed: