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Cyanocobalamin is a form of vitamin B. 12 used to treat and prevent vitamin B. 12 deficiency except in the presence of cyanide toxicity. [7][8][2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
The structure of vitamin B 12 was the first low-molecular weight natural product determined by x-ray analysis rather than by chemical degradation. Thus, while the structure of this novel type of complex biomolecule was established, its chemistry remained essentially unknown; exploration of this chemistry became one of the tasks of the vitamin's chemical synthesis.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. [2] It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. [3]
6% (< 60 years old), 20% (> 60 years old) [4] Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [5] Symptoms can vary from none to severe. [1] Mild deficiency may have few or absent symptoms. [1]
Methylcobalamin, another biologically active form. The dark red crystals dissolve in water giving cherry-colored solutions. Cobalamin biosynthesis is the process by which bacteria and archea make cobalamin, vitamin B 12. Many steps are involved in converting aminolevulinic acid via uroporphyrinogen III and adenosylcobyric acid to the final ...
In enzymology, a cyanocobalamin reductase (cyanide-eliminating) ( EC 1.16.1.6) is an enzyme that catalyzes the chemical reaction. The 3 substrates of this enzyme are cob (I)alamin, cyanide, and NADP +, whereas its 3 products are cyanocob (III)alamin, NADPH, and H + . This enzyme belongs to the family of oxidoreductases, specifically those that ...
B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism and synthesis of red blood cells. [1][2] They are a chemically diverse class of compounds. [1] Dietary supplements containing all eight are referred to as a vitamin B complex. Individual B vitamins are referred to by B-number or by chemical name, such ...
Adenosylcobalamin (AdoCbl), also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin (MeCbl), one of the biologically active forms of vitamin B 12. [1] Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosyl ...