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The expiration date for patent protection of lisdexamfetamine in the US was 24 February 2023. [134] The Canadian patent expires 20 years from the filing date of 1 June 2004. [135] Production quotas for 2016 in the United States were 29,750 kg. [136]
Drug expiration. Drug expiration is the date after which a drug might not be suitable for use as manufactured. Consumers can determine the shelf life for a drug by checking its pharmaceutical packaging for an expiration date. Drugs which are past their shelf life can decompose [1] and either be ineffective [2] or even harmful. [2]
Semaglutide is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management. [ 19 ] [ 20 ] [ 21 ] It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain .
Alpidem (Ananxyl) 1995. Worldwide. Not approved in the US, withdrawn in France in 1994 [ 4 ] and the rest of the market in 1995 because of rare but serious hepatotoxicity. [ 3 ][ 5 ] Alosetron (Lotronex) 2000. US. Serious gastrointestinal adverse events; ischemic colitis; severe constipation. [ 2 ] Reintroduced 2002 with restricted indication ...
In 2016, sertraline was the most commonly prescribed psychotropic medication in the United States. [17] In 2022, it was the eleventh most commonly prescribed medication in the United States, with more than 39 million prescriptions. [18] [19] In Australia, it was one of the top 10 most prescribed medications between 2017 and 2023. [20]
In 2006, Forest Laboratories was granted an 828-day (2 years and 3 months) extension on its US patent for escitalopram. [82] This pushed the patent expiration date from 7 December 2009, to 14 September 2011. Together with the 6-month pediatric exclusivity, the final expiration date was 14 March 2012.
Cariprazine, sold under the brand name Vraylar among others, is an atypical antipsychotic developed by Gedeon Richter, [ 8 ] which is used in the treatment of schizophrenia, bipolar mania, [ 9 ] bipolar depression, [ 10 ] and major depressive disorder. [ 6 ]
The expiration date of pharmaceuticals specifies the date the manufacturer guarantees the full potency and safety of a drug. Most medications continue to be effective and safe for a time after the expiration date. A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. [7]