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Clarithromycin, sold under the brand name Biaxin among others, is an antibiotic used to treat various bacterial infections. [6] This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. [6] Clarithromycin can be taken by mouth as a tablet or liquid or can be infused intravenously. [6]
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
It has an elimination half-life of 2-3 hours in adults, which is prolonged in renal failure. Approved indications include community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections. It was patented in 1980 and approved for medical use in 1989. [1]
Urinary tract infections, bacterial prostatitis, community-acquired pneumonia, bacterial diarrhea, mycoplasmal infections, gonorrhea: Nausea (rare), irreversible damage to central nervous system (uncommon), tendinosis (rare) Inhibits the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription ...
In areas of low clarithromycin resistance, including the United States, a 14-day course of "triple therapy" with an oral proton pump inhibitor, clarithromycin 500 mg, and amoxicillin 1 g (or, if penicillin allergic, metronidazole 500 mg), all given twice daily for 14 days, is recommended for first-line therapy. This regimen can achieve rates of ...
Complicated urinary tract infections [ edit ] A 2015 systematic review found little evidence that would support the identification of a best antimicrobial regimen for complicated urinary tract infections , but identified three high-quality trials supporting high cure rates with doripenem, including in patients with levofloxacin -resistant E ...