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Alpha-keratin, or α-keratin, is a type of keratin found in mammalian vertebrates. This protein is the primary component in hairs , horns , claws , nails and the epidermis layer of the skin . α-keratin is a fibrous structural protein , meaning it is made up of amino acids that form a repeating secondary structure.
The growth rate of hair varies from individual to individual depending on their age, genetic predisposition and a number of environmental factors. [14] It is commonly stated that hair grows about 1 cm per month on average; however reality is more complex, since not all hair grows at once.
Hair is a stratified squamous keratinized epithelium made of multi-layered flat cells whose rope-like filaments provide structure and strength to the hair shaft. The protein called keratin makes up hair and stimulates hair growth. Hair follows a specific growth cycle with three distinct and concurrent phases: anagen, catagen, and telogen. Each ...
Microscopy of keratin filaments inside cells. Keratin (/ ˈ k ɛr ə t ɪ n / [1] [2]) is one of a family of structural fibrous proteins also known as scleroproteins.It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin in vertebrates.
The relative alignment of the keratin fibrils significantly impacts the mechanical properties. In human hair the filaments of alpha keratin are highly aligned, giving a tensile strength of approximately 200MPa. This tensile strength is an order of magnitude higher than human nails (20MPa), because human hair's keratin filaments are more aligned ...
A nail is a protective plate characteristically found at the tip of the digits (fingers and toes) of all primates, corresponding to the claws in other tetrapod animals. . Fingernails and toenails are made of a tough rigid protein called alpha-keratin, a polymer also found in the claws, hooves, and horns of ver
Overall, keratin type 2 plays a crucial role in maintaining the strength and integrity of the skin, hair, and nails. Mutations in keratin genes can lead to various genetic disorders that affect these tissues, such as epidermolysis bullosa simplex , a rare condition characterized by blistering and erosion of the skin and mucous membranes.
74127 Ensembl ENSG00000167767 ENSMUSG00000037185 UniProt Q6KB66 Q0VBK2 RefSeq (mRNA) NM_001081492 NM_182507 NM_028770 RefSeq (protein) NP_001074961 NP_872313 NP_083046 Location (UCSC) Chr 12: 52.17 – 52.19 Mb Chr 15: 101.25 – 101.27 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Keratin 80, also known as KRT80, is a protein which in humans is encoded by the KRT80 gene. Function ...