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The body can’t produce tryptophan, so you must get it from your diet, it notes. Turkey is a good source, but so is cheese, chicken, fish, milk, peanuts, egg whites and soy beans.
Holiday staples include delicious foods like honey-baked ham, roasted beef tenderloin, and one of the most iconic holiday foods of them all: turkey.
Yes, tryptophan indirectly has a role in making you feel sleepy. But that doesn't mean turkey is the primary culprit when you hit a post-Thanksgiving slump. The real reason is much more complicated.
Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent. Tryptophan is also a precursor to the neurotransmitter serotonin, the hormone melatonin, and vitamin B 3 (niacin). [4] It is encoded by the codon UGG.
Indoleamine 2,3-dioxygenase is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway.. IDO is an important molecule in the mechanisms of tolerance and its physiological functions include the suppression of potentially dangerous inflammatory processes in the body. [16]
Familial hypertryptophanemia has an autosomal recessive pattern of inheritance.. Hypertryptophanemia is believed to be inherited in an autosomal recessive manner. [2] This means a defective gene responsible for the disorder is located on an autosome, and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder.
If you think holiday turkey is responsible for the afternoon sleepiness you feel, you’d be wrong, experts say. Here’s the real gobble.
Tryptophan 2,3-dioxygenase plays a central role in the physiological regulation of tryptophan flux in the human body, as part of the overall biological process of tryptophan metabolism. TDO catalyses the first and rate-limiting step of tryptophan degradation along the kynurenine pathway and thereby regulates systemic tryptophan levels. [5]