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Confounding is defined in terms of the data generating model. Let X be some independent variable, and Y some dependent variable.To estimate the effect of X on Y, the statistician must suppress the effects of extraneous variables that influence both X and Y.
Graphical model: Whereas a mediator is a factor in the causal chain (top), a confounder is a spurious factor incorrectly implying causation (bottom). In statistics, a spurious relationship or spurious correlation [1] [2] is a mathematical relationship in which two or more events or variables are associated but not causally related, due to either coincidence or the presence of a certain third ...
A different set of techniques have been developed for "large-scale multiple testing", in which thousands or even greater numbers of tests are performed. For example, in genomics, when using technologies such as microarrays, expression levels of tens of thousands of genes can be measured, and genotypes for millions of genetic markers can be ...
Though there are many approximate solutions (such as Welch's t-test), the problem continues to attract attention [4] as one of the classic problems in statistics. Multiple comparisons: There are various ways to adjust p-values to compensate for the simultaneous or sequential testing of hypotheses. Of particular interest is how to simultaneously ...
The phenomenon may disappear or even reverse if the data is stratified differently or if different confounding variables are considered. Simpson's example actually highlighted a phenomenon called noncollapsibility, [32] which occurs when subgroups with high proportions do not make simple averages when combined. This suggests that the paradox ...
Any non-linear differentiable function, (,), of two variables, and , can be expanded as + +. If we take the variance on both sides and use the formula [11] for the variance of a linear combination of variables (+) = + + (,), then we obtain | | + | | +, where is the standard deviation of the function , is the standard deviation of , is the standard deviation of and = is the ...
For example, consider the following equation: + = If we multiply both sides by zero, we get, = This is true for all values of , so the solution set is all real numbers. But clearly not all real numbers are solutions to the original equation.
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