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There are different models for the stomach and small intestine (TIM-1 and Tiny-TIM) and a model simulating the physiological conditions of the colon (TIM-2). The TIM-1 system consists of a stomach compartment and 3 compartments for the small intestine, the duodenum, jejunum and ileum.
Creating a cellular model has been a particularly challenging task of systems biology and mathematical biology. It involves the use of computer simulations of the many cellular subsystems such as the networks of metabolites, enzymes which comprise metabolism and transcription, translation, regulation and induction of gene regulatory networks. [4]
MNase digestion of chromatin was key to early studies of chromatin structure; being used to determine that each nucleosomal unit of chromatin was composed of approximately 200bp of DNA. [13] This, alongside Olins’ and Olins’ “beads on a string” model, [14] confirmed Kornberg’s ideas regarding the basic chromatin structure. [15]
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Control of the digestive system is also maintained by ENS, which can be thought of as a digestive brain that can help to regulate motility, secretion and growth. Sensory information from the digestive system can be received, integrated and acted upon by the enteric system alone. When this occurs, the reflex is called a short reflex. [4]
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