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Trilostane was the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. [citation needed] Only one other drug, Anipryl (veterinary brand name) selegiline, is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's. [30]
A study of 66 dogs with Cushing's found 91% of dogs to have either polyuria or polydipsia, 79% to have polyphagia, and 77% to have alopecia. [ 4 ] Signs of ectopic adrenocorticotropic hormone secretion that accompany the rapidly progressing physical changes are high plasma levels of adrenocorticotropic hormones and cortisol alongside hypokalaemia .
amitriptyline – tricyclic antidepressant used to treat separation anxiety, excessive grooming dogs and cats; amlodipine – calcium channel blocker used to decrease blood pressure; amoxicillin – antibacterial; apomorphine – emetic (used to induce vomiting) artificial tears – lubricant eye drops used as a tear supplement
Cushing's can be caused by overuse of steroid medications; in some cases, stopping the medication is enough to solve the problem. [117] Diagnosis can be difficult as there are no tests with both high sensitivity and specificity. [119] Treatments include mitotane, trilostane, [120] [121] ketoconazole, or selegiline.
Category: Dog medications. 1 language. ... Trilostane; Z. Zeuterin This page was last edited on 21 June 2021, at 01:26 (UTC). Text is available under the ...
Despite similar symptoms and blood test results to Cushing's disease, evaluation of dogs with SARDS did not reveal any tumors in the pituitary or adrenal glands, [9] and recent work has indicated significant differences in the clinical and laboratory test parameters between the two diseases. [10]
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