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The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
General anaesthesia (UK) or general anesthesia (US) is medically induced loss of consciousness that renders a patient unarousable even by painful stimuli. [5] It is achieved through medications, which can be injected or inhaled, often with an analgesic and neuromuscular blocking agent .
More than 100 years ago, a unifying theory of anesthesia was proposed based on the oil partition coefficient. In the 70s this concept was extended to the disruption of lipid partitioning. [ 28 ] Partitioning itself is an integral part of forming the ordered domains in the membrane, and the proposed mechanism is very close to the current ...
General anaesthetics (or anesthetics) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma that causes lack of awareness to painful stimuli, sufficient to facilitate surgical applications in clinical and veterinary practice.
Subsequently, the term and variant spellings like anæsthesia are used in medical literature signifying "insensibility". [28] In 1846, in a letter, Oliver Wendell Holmes proposed the term anesthesia to be used for the state induced by an agent and anesthetic for the agent itself. Holmes motivates this with earlier uses of anesthesia in medical ...
In light of the preclinical and clinical literature, in 2016, the U.S. Food and Drug Administration issued a communication [9] containing a warning that "repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than three years or in pregnant women during their third trimester may ...
Anesthesia is a combination of the endpoints (discussed above) that are reached by drugs acting on different but overlapping sites in the central nervous system. General anesthesia (as opposed to sedation or regional anesthesia) has three main goals: lack of movement , unconsciousness, and blunting of the stress response. In the early days of ...
Orchestrated objective reduction (Orch OR) is a theory postulating that consciousness originates at the quantum level inside neurons (rather than being a product of neural connections). The mechanism is held to be a quantum process called objective reduction that is orchestrated by cellular structures called microtubules .