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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
2A peptides trigger the ribosome to skip peptide bond formation between the glycine (G) and proline (P) near the C-terminus of the 2A peptide, resulting in the peptide located upstream of the 2A peptide having extra amino acids appended to its C-terminus while the protein downstream the 2A peptide will have an extra proline on its N-terminus.
12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb Chr 2: 133.39 – 133.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Function BMP-2 like other bone morphogenetic ...
He has remained at MIT for his entire academic career, becoming a full professor in 1987 and the Edwin C. Whitehead Professor in 1991. Sauer assumed his current appointment as the Salvador E. Luria Professor of Biology in 1999. He has held a number of service roles at MIT and spent five years, from 1999 to 2004, as the head of the biology ...
The MIT Department of Biology ("Course VII") is a center for research and teaching in the life sciences. Many members of the faculty hold joint appointments with ...
[1] In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR. Mutations in the HLA gene complex can lead to bare lymphocyte syndrome (BLS), which is a type of MHC class II deficiency.
In molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels K ir 6.x (6.1 ...
N2a cells have been used to study neurite outgrowth, [1] neurotoxicity, [2] Alzheimer's disease, [8] asymmetric division of mammalian cell lines, [9] adenoviral transduction, and the diagnosing of rabies. One specific research applications is the differentiation of N2a cells into dopamine neurons for potential use in treating Parkinson's Disease.