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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [2] [3] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [4]
2A peptides trigger the ribosome to skip peptide bond formation between the glycine (G) and proline (P) near the C-terminus of the 2A peptide, resulting in the peptide located upstream of the 2A peptide having extra amino acids appended to its C-terminus while the protein downstream the 2A peptide will have an extra proline on its N-terminus.
The MIT Department of Biology ("Course VII") is a center for research and teaching in the life sciences. Many members of the faculty hold joint appointments with ...
The herpes simplex virus protein ICP34.5 also activates protein phosphatase 1, which overcomes the cellular stress response to viral infection; protein kinase R is activated by the virus' double-stranded RNA, and protein kinase R then phosphorylates a protein called eukaryotic initiation factor-2A (eIF-2A), which inactivates eIF-2A.
He has remained at MIT for his entire academic career, becoming a full professor in 1987 and the Edwin C. Whitehead Professor in 1991. Sauer assumed his current appointment as the Salvador E. Luria Professor of Biology in 1999. He has held a number of service roles at MIT and spent five years, from 1999 to 2004, as the head of the biology ...
Tyler Jacks is a David H. Koch Professor of Biology at the Massachusetts Institute of Technology (MIT), a long-time HHMI investigator, and Founding Director of the David H. Koch Institute for Integrative Cancer Research, which brings together biologists and engineers to improve detection, diagnosis, and treatment of cancer. [1]
[1] [2] He was named a Howard Hughes Medical Investigator in 2000. [3] In 2009, Bell received the NAS Award in Molecular Biology and was named a member of the National Academy of Sciences itself in 2017. [4] MIT appointed Bell the Uncas and Helen Whitaker Professor of Biology in 2018. [5] He is a member of the Editorial Board for Genes ...
Jonathan S. Weissman is the Landon T. Clay Professor of Biology at the Massachusetts Institute of Technology, a member of the Whitehead Institute, and a Howard Hughes Medical Institute Investigator. From 1996 to 2020, he was a faculty member in the department of cellular molecular pharmacology at the University of California, San Francisco .