Ads
related to: what does protease do hiv treatment medications- Treatment Costs & Savings
See If You Are Eligible For Savings
Or Assistance Programs.
- Helpful Resources
Learn About An HIV Treatment
And Discover More About Dosing.
- Long-Acting HIV Treatment
Injections Just Every Other Month
With A Flexible Treatment Window.
- HIV Treatment Injectable
Learn About A Treatment Option
And Find More Info Online Today.
- Helpful Patient Tools
Find Information For Patients Here.
Visit The Official Patient Website.
- Get Treatment Resources
See Tools Specifically For Patients
About Dosing, Savings And More.
- Treatment Costs & Savings
Search results
Results From The WOW.Com Content Network
Some of the most well known are antiviral drugs widely used to treat HIV/AIDS, hepatitis C and COVID-19. These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.
The first HIV protease inhibitor, saquinavir, is a peptidomimetic hydroxyethylamine [6] and was marketed in 1995. [18] It is a transition state analogue of a native substrate of the protease. [6] The observation that HIV-1 protease cleaves the sequences containing the dipeptides Tyr-Pro or Phe-Pro was the basic design criterion. [19]
[citation needed] It is important to recognized that socioeconomic status, access to medical care, geographic location, public policy, race and ethnicity all play a pivotal role in the treatment and management of HIV/AIDS. The lack of sufficient and constant income does limit the options for food, treatment, and medications.
HIV includes a protease, and so considerable research has been performed to find "protease inhibitors" to attack HIV at that phase of its life cycle. [31] Protease inhibitors became available in the 1990s and have proven effective, though they can have unusual side effects, for example causing fat to build up in unusual places. [32]
As HIV-1 PR can only function as a dimer, the mature protease contains two Asp25 amino acids, one from each monomer, that act in conjunction with each other as the catalytic residues. [9] Additionally, HIV protease has two molecular "flaps" which move a distance of up to 7 Å when the enzyme becomes associated with a substrate. [10]
Nelfinavir, sold under the brand name Viracept, is an antiretroviral medication used in the treatment of HIV/AIDS.Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs.
Ads
related to: what does protease do hiv treatment medications