Ads
related to: adaptor protein 2
Search results
Results From The WOW.Com Content Network
AP-2 complex. The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. [1] It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene. [5] This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small ...
Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. [2] The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and the monomeric GGA (Golgi-localising, Gamma-adaptin ear homology, ARF-binding proteins) adaptors.
GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene. [5] [6] [7]
The protein encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [7]
Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes. [1] There are several types of adaptin, each related to a different AP complex.
161 11772 Ensembl ENSG00000281385 ENSG00000280759 ENSG00000183020 ENSMUSG00000002957 UniProt O94973 P17427 RefSeq (mRNA) NM_001242837 NM_012305 NM_007459 NM_001357068 RefSeq (protein) NP_001229766 NP_036437 NP_031485 NP_001343997 Location (UCSC) Chr 11: 0.92 – 1.01 Mb Chr 7: 141.14 – 141.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-2 complex subunit alpha-2 is a protein ...
Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves, [ 2 ] instead mediating specific protein–protein interactions that drive the formation of protein complexes .