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Reed–Sternberg cells are CD30 and CD15 positive except in the lymphocyte predominance type where they are negative, but are usually positive for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value.
Reed-Sternberg and Hodgkin (RSH) cells are rarely seen, and immunohistochemistry shows a different pattern on the malignant cells; RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like CD20, CD22, and CD79a and also express the common leukocyte antigen CD45, which is ...
For the other forms, although the traditional B-cell markers (such as CD20) are not expressed on all cells, [29] Reed–Sternberg cells are usually of B cell origin. [ 30 ] [ 31 ] Although Hodgkin's is now frequently grouped with other B-cell malignancies, some T-cell markers (such as CD2 and CD4 ) are occasionally expressed. [ 32 ]
Reed–Sternberg cell variants and inflammation, usually broad sclerotic bands that consist of collagen CD15, CD30 Most common in young adults, often arises in the mediastinum or cervical lymph nodes. Mixed cellularity Hodgkin lymphoma; Second-most common form of Hodgkin lymphoma Many classic Reed–Sternberg cells and inflammation CD15, CD30
It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands. [ citation needed ] The British National Lymphoma Investigation further categorized NSHL based upon Reed–Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first ...
RS cells are distinctively large and have multiple nuclei, as in his case, or one nucleus with two lobes. RS cells express CD30 cell surface protein (a member of the tumor necrosis factor receptor family) and CD15 (a blood group antigen carbohydrate on the cell surface). [19]
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