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Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]
Laxatives are safe to use occasionally, but the growing overuse is concerning professionals. Instead, doctors suggest, those who want to have more regular bowel movements should eat more fruit ...
Laxatives are not a weight-loss aid, but doctors worry some people are still not getting the message — especially as they look for cheaper, more accessible alternatives to weight-loss drugs like ...
The next time you're backed up, consider trying these natural laxatives as your first line of defense. Prunes “Dried plums (prunes) have both kinds of fiber plus they contain sorbitol, ...
This list is not limited to drugs that were ever approved by the FDA. Some of them (lumiracoxib, rimonabant, tolrestat, ximelagatran and ximelidine, for example) were approved to be marketed in Europe but had not yet been approved for marketing in the US, when side effects became clear and their developers pulled them from the market.
Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.