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The exact mechanism of action of silicone gel sheeting has not been fully studied. Currently, many proposed mechanisms explain the efficacy of such treatment, including the occlusion and hydration effect, increased body surface temperature, polarized electric charge, immunological effects, etc. [9] The occlusion and hydration effect is the most studied mechanism of action.
The tissue injury in SCARs is initiated principally by CD8 + or CD4 + T cells. Once drug-activated, these lymphocytes elicit immune responses to self tissues that can result in SCARs drug reactions by mechanisms which vary with the type of disorder that develops. Salient elements mediating tissue injury for each type of disorder include: [2] [13]
Scar tissue is composed of the same protein as the tissue that it replaces, but the fiber composition of the protein is different; instead of a random basketweave formation of the collagen fibers found in normal tissue, in fibrosis the collagen cross-links and forms a pronounced alignment in a single direction. [1]
Peyronie’s disease (growth of scar tissue in the privates) Shrinkage and numbness of the privates. ... The other side effects, such as breast enlargement, and breast tenderness, were only ...
Appropriate treatment of a keloid scar is age-dependent: radiotherapy, anti-metabolites and corticosteroids would not be recommended to be used in children, in order to avoid harmful side effects, like growth abnormalities. [14] In adults, corticosteroids combined with 5-FU and PDL in a triple therapy, enhance results and diminish side effects ...
The tissue in the lungs becomes thick and stiff, which affects the tissue that surrounds the air sacs in the lungs. [7] Symptoms typically include gradual onset of shortness of breath and a dry cough. [1] Other changes may include feeling tired, and clubbing abnormally large and dome shaped finger and toenails. [1]
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue. [1] [2]
This can help prevent discomfort or changes to the skin at the injection site (like scar tissue buildup). ... Common semaglutide side effects include: Nausea. Vomiting. Diarrhea. Stomach pain.